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Home - Products - Metabolic Enzyme/Protease - P450 - Guan-fu base A

Guan-fu base A

CAS No. 1394-48-5

Guan-fu base A ( Guanfu base A )

Catalog No. M21481 CAS No. 1394-48-5

Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Guan-fu base A
  • Note
    Research use only not for human use.
  • Brief Description
    Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
  • Description
    Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
  • Synonyms
    Guanfu base A
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    CYP2D6; HERG channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1394-48-5
  • Formula Weight
    429.5
  • Molecular Formula
    C24H31NO6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(=O)O[C@H]1C[C@@]2(CN3[C@@H]4[C@H]2[C@]5(C1)[C@H]3[C@]6(C([C@H]7[C@H]([C@@H]5[C@]6(C4)CC7=C)O)OC(=O)C)O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sun J et al. Guanfu base A an antiarrhythmic alkaloid of Aconitum coreanum Is a CYP2D6 inhibitor of human monkey and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24.
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